2024

Zhang Y, David NL, Pesaresi T, Andrews RE, Kumar GVN, Chen H, Qiao W, Yang J, Patel K, Amorim T, Sharma AX, Liu S, Steinhauser ML. Noncoding variation near UBE2E2 orchestrates cardiometabolic pathophenotypes through polygenic effectors. JCI Insight. 2024 Dec 10:e184140. doi: 10.1172/jci.insight.184140. Epub ahead of print. PMID: 39656538.

Guillermier C, Kumar NV, Bracken RC, Alvarez D, O'Keefe J, Gurkar A, Brown JD, Steinhauser ML. Nanoscale imaging of DNA-RNA identifies transcriptional plasticity at heterochromatin. Life Sci Alliance. 2024 Sep 17;7(12):e202402849. doi: 10.26508/lsa.202402849. PMID: 39288993; PMCID: PMC11408601.

Steinhauser ML. Unhealthy visceral fat is associated with improved efficacy of immunotherapy in endometrial cancer. J Clin Invest. 2024 Sep 3;134(17):e183675. doi: 10.1172/JCI183675. PMID: 39225094; PMCID: PMC11364398.

Zhu B, Liu S, David NL, Dion W, Doshi NK, Siegel LB, Amorim T, Andrews RE, Kumar GVN, Li H, Irfan S, Pesaresi T, Sharma AX, Sun M, Fazeli PK, Steinhauser ML. Evidence for ~12-h ultradian gene programs in humans. NPJ Biol Timing Sleep. 2024;1(1):4. doi: 10.1038/s44323-024-00005-1. Epub 2024 Aug 9. PMID: 39148626; PMCID: PMC11325440.

2022

Monji A, Zhang Y, Kumar GVN, Guillermier C, Kim S, Olenchock B, Steinhauser ML. A Cycle of Inflammatory Adipocyte Death and Regeneration in Murine Adipose Tissue. Diabetes. 2022 Mar 1;71(3):412-423. doi: 10.2337/db20-1306. PMID: 35040481

2021

Gyngard F, Trakimas L, Steinhauser ML. High-Fidelity Quantification of Cell Cycle Activity with Multi-Isotope Imaging Mass Spectrometry. Methods Mol Biol. 2021;2158:257-268. doi: 10.1007/978-1-0716-0668-1_19. PMID: 32857379

2020

Fazeli PK, Zhang Y, O'Keefe J, Pesaresi T, Lun M, Lawney B, Steinhauser ML. Prolonged fasting drives a program of metabolic inflammation in human adipose tissue. Mol Metab. 2020 Dec;42:101082. doi: 10.1016/j.molmet.2020.101082. Epub 2020 Sep 28. PMID: 32992039

Narendra DP, Steinhauser ML. Metabolic Analysis at the Nanoscale with Multi-Isotope Imaging Mass Spectrometry (MIMS). Curr Protoc Cell Biol. 2020 Sep;88(1):e111. doi: 10.1002/cpcb.111. PMID: 32706155

Zhang Y, Guillermier C, De Raedt T, Cox AG, Maertens O, Yimlamai D, Lun M, Whitney A, Maas RL, Goessling W, Cichowski K, Steinhauser ML. Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity. iScience. 2020 Aug 21;23(8):101355. doi: 10.1016/j.isci.2020.101355. Epub 2020 Jul 10. PMID: 32712466

Weeks O, Bossé GD, Oderberg IM, Akle S, Houvras Y, Wrighton PJ, LaBella K, Iversen I, Tavakoli S, Adatto I, Schwartz A, Kloosterman D, Tsomides A, Charness ME, Peterson RT, Steinhauser ML, Fazeli PK, Goessling W. Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. J Clin Invest. 2020 May 1;130(5):2252-2269. doi: 10.1172/JCI132139. PMID: 32202514

Narendra DP, Guillermier C, Gyngard F, Huang X, Ward ME, Steinhauser ML. Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover. J Cell Biol. 2020 Jan 6;219(1):e201901097. doi: 10.1083/jcb.201901097. PMID: 31719114

2019

Guillermier C, Doherty SP, Whitney AG, Babaev VR, Linton MF, Steinhauser ML*, Brown JD. Imaging mass spectrometry reveals heterogeneity of proliferation and metabolism in atherosclerosis. JCI Insight. 2019. Jun 6;4(11):e128528. PMID: 31167964*co-senior author

Fazeli PK, Lee H, Steinhauser ML. Aging is a powerful risk factor for type 2 diabetes mellitus independent of body mass index. Gerontology. 2019. Sep 10:epub. PMID: 31505500

Liu H, Zhang CH, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A,  Kostka D, Ding J, Bar-Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-Múgica M, Steinhauser ML, Bernhard Kühn. Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med. 2019. Oct 9;11(513). PMID: 311597755

Gyngard F, Steinhauser ML. Biological explorations with nanoscale secondary ion mass spectrometry. J Anal Atom Spectrom. 2019; 34, 1534-1545.

2018

Lu J, Baccei A, Lummertz da Rocha E, Guillermier C, McManus S, Finney LA, Zhang C, Steinhauser ML, Li H, Lerou PH. Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm. Stem Cell Res. 2018. 28: 48-55. PMID: 29427839

Wildburger NC, Gyngard F, Guillermier C, Patterson BW, Elbert D, Mawuenyega KG, Schneider T, Green K, Roth R, Schmidt RE, Cairns NJ, Benzinger TLS, Steinhauser ML, Bateman RJ. Amyloid-b plaques in clinical Alzheimer’s Disease brain incorporate stable isotope tracer in vivo and exhibit nanoscale heterogeneity. Front Neurol. 2018. 9(169): 1-12. PMID: 29623063

Vujic A, Lerchenmuller C, Wu TD, Guillermier C, Rabolli CP, Gonzalez E, Senyo SE, Liu X, Guerquin-Kern JL, Steinhauser ML, Lee RT, Rosenzweig A. Exercise induces new cardiomyocyte generation in the adult mammalian heart. Nat Commun. 2018. 9(1): 1659. PMID: 29695718

Steinhauser ML, Olenchock BA, O’Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK. The circulating metabolome of human starvation. JCI Insight. 2018. 23(16). PMID: 30135314

Zhang Y, Federation AJ, Kim S, O’Keefe J, Lun M, Xiang D, Brown JD, Steinhauser ML. Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity. J Clin Invest. 2018. 128(11): 4898-4911. PMID: 30277475

Cox A, Tsomides A, Yimlamai D, Hwang K, Miesfeld J, Galli G, Fowl B, Fort M, Ma K, Sullivan M, Hosios A, Snay E, Yuan M, Brown K, Lien E, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link BA, Vander Heiden MG, Camargo F. Goessling W. Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. EMBO J. 2018. 37(22): e100294. PMID: 30348863

2017

Guillermier C, Poczatek JC, Taylor WR, Steinhauser ML. Quantitative imaging of deuterated metabolic tracers in biological tissues with nanoscale secondary ion mass spectrometry. Int J Mass Spectrom. 2017. 422: 42-50. PMID: 29276427

Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW Jr, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM, Smith AV, Zhang Y, Homuth G, Kissebah AH, Kullberg J, Laqua R, Launer LJ, Nauck M, Olivier M, Peyser PA, Terry JG, Wojczynski MK, Yao J, Bielak LF, Blangero J, Borecki IB, Bowden DW, Carr JJ, Czerwinski SA, Ding J, Friedrich N, Gudnason V, Harris TB, Ingelsson E, Johnson AD, Kardia SL, Langefeld CD, Lind L, Liu Y, Mitchell BD, Morris AP, Mosley TH Jr, Rotter JI, Shuldiner AR, Towne B, Völzke H, Wallaschofski H, Wilson JG, Allison M, Lindgren CM, Goessling W, Cupples LA, Steinhauser ML*, Fox CS. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet. 2017. 49: 125-30. PMID: 27918534 *co-corresponding author

Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francois-Saint-Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser M. L., Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity.  JCI Insight. 2017 Mar 9;2(5):e90349. doi: 10.1172/jci.insight.90349. PMID: 28289709 

2016

Kumar, S., Rajagopalan, S., Sarkar, P., Dorward, D. W., Peterson, M. E., Liao, H.-S., Steinhauser, M. L., … Long, E. O. (2016). Zinc-induced polymerization of killer-cell Ig-like receptor into filaments promotes its inhibitory function at cytotoxic immunological synapses. Molecular Cell, 62(1), 21–33. http://doi.org/10.1016/j.molcel.2016.03.009

Hosios, A. M., Hecht, V. C., Danai, L. V., Johnson, M. O., Rathmell, J. C., Steinhauser, M. L., … Vander Heiden, M. G. (2016). Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells. Developmental Cell, 36(5), 540–549. http://doi.org/10.1016/j.devcel.2016.02.012

2015

Fazeli, P. K., Lun, M., Kim, S. M., Bredella, M. A., Wright, S., Zhang, Y., … Steinhauser, M. L. (2015). FGF21 and the late adaptive response to starvation in humans. The Journal of Clinical Investigation, 125(12), 4601–4611. http://doi.org/10.1172/JCI83349

2014

Steinhauser, M. L., Guillermier, C., Wang, M., & Lechene, C. P. (2014). Approaches to increasing analytical throughput of human samples with multi-isotope imaging mass spectrometry. Surface and Interface Analysis : SIA, 46(Suppl 1), 165–168. http://doi.org/10.1002/sia.5580

Steinhauser, M. L., Guillermier, C., Wang, M., & Lechene, C. P. (2014). Quantifying cell division with deuterated water and multi-isotope imaging mass spectrometry (MIMS). Surface and Interface Analysis : SIA, 46(Suppl 1), 161–164. http://doi.org/10.1002/sia.5581

Kim, S. M., Lun, M., Wang, M., Senyo, S. E., Guillermier, C., Patwari, P., & Steinhauser, M. L. (2014). Loss of White Adipose Hyperplastic Potential Is Associated with Enhanced Susceptibility to Insulin Resistance. Cell Metabolism, 20(6), 1049–1058. http://doi.org/10.1016/j.cmet.2014.10.010

Guillermier, C., Steinhauser, M. L., & Lechene, C. P. (2014). Quasi-simultaneous acquisition of nine secondary ions with seven detectors on NanoSIMS50L: application to biological samples. Surface and Interface Analysis : SIA, 46(Suppl 1), 150–153. http://doi.org/10.1002/sia.5496